秘曉林，博士，教授，博士研究生導師。入選中國科學(xué)院“引進(jìn)國外杰出人才--百人計劃”，遼寧省“攀登學(xué)者”。國家重大科學(xué)研究計劃、國家自然科學(xué)基金、博士后科學(xué)基金、美國國家科學(xué)基金研究生項目等評議人，SCI雜志International Journal of Nanomedicine顧問(wèn)編委，PLoS ONE、Current Proteomics編委，中國生化藥物雜志編委，中國環(huán)境誘變劑學(xué)會(huì )理事，遼寧省醫學(xué)會(huì )醫學(xué)遺傳學(xué)分會(huì )副主任委員，Biomaterials、Genetics、International Journal of Nanomedicine等SCI雜志審稿人。主持國家重點(diǎn)基礎研究計劃“973”課題、國家自然科學(xué)基金項目、中國科學(xué)院創(chuàng )新項目等。
1990年畢業(yè)于蘭州大學(xué)生物化學(xué)專(zhuān)業(yè)，獲理學(xué)學(xué)士學(xué)位；1996年畢業(yè)于衛生部蘭州生物制品研究所免疫學(xué)和微生物學(xué)專(zhuān)業(yè)，獲碩士學(xué)位；1999年畢業(yè)于中國預防醫學(xué)科學(xué)院病毒學(xué)研究所病原生物學(xué)專(zhuān)業(yè)，獲博士學(xué)位。同年赴美國，在國立衛生研究院（National Institutes of Health）國家癌癥研究所（National Cancer Institute）從事博士后研究，隨后任職美國國立衛生研究院國家癌癥研究所研究學(xué)者。作為通訊作者，研究成果發(fā)表在Proceedings of National Academy of Sciences USA, Oncogene, Biomaterials, Human Molecular Genetics, Journal of Cell Science等國際知名學(xué)術(shù)期刊。
1. Li D., Liu Y., Pei C., Zhang P., Pan L., Xiao J., Meng S., Yuan Z., Bi X. * miR-285-Yki/Mask double-negative feedback loop mediates blood-brain barrier integrity in Drosophila. Proceedings of National Academy of Sciences USA. 2017. 114(12): E2365-E2374. IF 9.7
2. Song F., Li D., Wang Y., Bi X.* Drosophila Caliban mediates G1-S transition and ionizing radiation induced S phase checkpoint. Cell Cycle. 2018. 17(18): 2256-2267. IF 3.3
3. Yuan Q., Tian R., Zhao H., Li L., Bi X. * Multiple arginine residues are methylated in Drosophila Mre11 and required for survival following ionizing radiation. G3: Genes Genomes Genetics. 2018. 8 (6): 2099-2106. IF 2.7
4. Li D. and Bi X. * Effect of Teratogens on Development of Drosophila melanogaster. Teratogenicity Testing: Methods and Protocols. Methods in Molecular Biology. Springer. 2018. 1797:233-241.
5. Cong, W., Wang, P., Qu, Y., Tang, J., Bai, R., Zhao, Y., Chen, C., Bi, X. * Evalutation of the influence of Fullerenol on aging and stress resistance using Caenorhabditis elegans. Biomaterials. 2015. 42:78-86. IF 8.6
6. Jiang K., Liu M., Lin G., Mao B., Cheng W., Liu H., Gal J., Zhu H., Yuan Z., Deng W., Liu Q., Gong P., Bi X. *, Meng S. * Tumor suppressor Spred2 interaction with LC3 promotes autophagosome maturation and induces autophagy-dependent cell death. Oncotarget. 2016. 7 (18): 25652-25667. IF 5.2
7. Qian X., Wang P., Xia Y., Dou T., Jin Q., Wang D., Hao D., Bi X. *, Ge G. *, Yang L. * A highly selective fluorescent probe for sensing activities of catechol-O-methyltransferase in complex biological samples. Sensors and Actuators B. 2016. 231:615–623. IF 5.4
8. Chen, H., Wang, B., Feng, W., Du, W., Ouyang, H., Chai, Z., Bi, X.* Oral Magnetite Nanoparticles Disturb the Development of Drosophila Melanogaster from Oogenesis to Adult Emergence. Nanotoxicology. 2015. 9(3):302-312. IF 7.9
9. Yuan, Q., Han, J., Cong, W., Ge, Y., Ma, D., Dai, Z., Li, Y., Bi, X. * Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with improved cell apoptosis and gene expression profile and reduced myelosuppression toxicity. International Journal of Nanomedicine. 2014. 9(1): 4829-4846. IF 4.3
10. Fang, G., Zhang, D., Yin, H., Zheng, L., Bi, X.*, Yuan, L.* Centlein maintains centrosome cohesion by bridging an interaction between C-Nap1 and Cep68. Journal of Cell Science. 2014. 127 :1631-1639. IF 5.4
11. Wang, Y., Wang, Z., Joshi, BH., Puri, R., Stultz, B., Yuan, Q., Bai, Y., Zhou, P., Yuan, Z., Hursh, DA., Bi, X.* The tumor suppressor Caliban regulates DNA damage induced apoptosis through p53-dependent and –independent activity. Oncogene. 2013. 32(33):3857-66. IF 8.6
12. Liu, W., Jiang, F., Bi, X.*, Zhang, Q*. Drosophila FMRP participates in DNA damage response by regulating G2/M cell cycle checkpoint and apoptosis. Human Molecular Genetics. 2012, 21(21):4655-68. IF 7.7
13. Kong, L., Yuan Y., Zhu, H., Li, Y., Guo, Q., Zhao, Y., Wang, Q., Bi, X.*, Gao,X*. The suppression of prostate LNCaP cancer cells growth by Selenium nanoparticles through Akt/Mdm2/AR controlled apoptosis. Biomaterials. 2011.32(27)：6515-6522. IF 7.6
15. Gao, G., Bi, X., Chen, J., Srikanta, D., Rong, YS. Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis. Proceedings of National Academy of Sciences USA. 2009. 106(26): 10728–10733.(Equal contribution). IF 9.4
16. Bi, X., Jones, T., Abbasi, F., Lee, H., Stultz, B., Hursh, D., Mortin, M. Drosophila Caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells. Oncogene. 2005. 24:8229-8239. IF 6.8
17. Bi, X., Srikanta, D., Fanti,L., Pimpinelli,S., Badugu,R., Kellum,R., Rong, Y.S. Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance. Proceedings of National Academy of Sciences USA. 2005. 102(42):15167-15172. IF 10.2
18. Bi, X., Gong, M., Srikanta, D., Rong, Y.S. Drophila ATM and Mre11 are essential for the G2/M checkpoint induced by low-dose irradiation. Genetics. 2005. 171:845-847. IF 4.4
19. Bi, X., Wei, S.D., Rong, Y.S. Telomere protection without a telomerase: the role of ATM and Mre11 in Drosophila telomere maintenance. Current Biology. 2004. 14:1348-1353. IF 11.9
20. Bi, X., Kajava, A., Demidenko, Z., Jones, T., Mortin, M. The carboxyl terminus of Prospero regulates its subcellular localization. Molecular and Cellular Biology. 2003. 23 (3): 1014-1024. IF 8.9
